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In vivo 31 P nuclear magnetic resonance studies of T 1 and T 2 relaxation times in rat brain and in rat brain tumors implanted to nude mice
Author(s) -
Remy C.,
Albrand J. P.,
Benabid A. L.,
Decorps M.,
Jacrot M.,
Riondel J.,
Foray M. F.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040207
Subject(s) - phosphocreatine , nuclear magnetic resonance , phosphomonoesters , homonuclear molecule , spin–lattice relaxation , relaxation (psychology) , coupling constant , spin echo , in vivo , nuclear magnetic resonance spectroscopy , chemistry , larmor precession , inorganic phosphate , physics , magnetic resonance imaging , biology , endocrinology , medicine , particle physics , nuclear quadrupole resonance , radiology , energy metabolism , organic chemistry , molecule , enzyme , microbiology and biotechnology , quantum mechanics , magnetic field
31 P NMR spin‐lattice ( T 1 ) and spin‐spin ( T 2 ) relaxation times of phosphocreatine, ATP, inorganic phosphate, and phosphomonoesters have been measured in vivo at 4.7 T in rat brain and rat brain tumors implanted on nude mice. The relaxation data were acquired using a phase‐cycled saturation‐recovery spin‐echo sequence. The problems associated with the phase modulation of the ATP lines by the homonuclear coupling constants were overcome by using selective refocusing pulses for the T 2 measurements. In all the metabolites, large differences (1 to 2 orders of magnitude) are observed between the two relaxation times. T 1 values in rat brain tumors are 30 to 90% longer than their counterparts in normal rat brain. T 2 values follow the same trend with smaller variations except for phosphocreatine values which seem much less sensitive to the metabolic state of the tissues. © 1987 Academic Press, Inc.