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In vivo determination of body iron stores by natural‐abundance deuterium magnetic resonance spectroscopy
Author(s) -
Irving Michael G.,
Brereton Ian M.,
Field James,
Doddrell David M.
Publication year - 1987
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910040111
Subject(s) - deuterium , in vivo , nuclear magnetic resonance spectroscopy , chemistry , nuclear magnetic resonance , relaxation (psychology) , electron paramagnetic resonance spectroscopy , spectroscopy , abundance (ecology) , paramagnetism , analytical chemistry (journal) , radiochemistry , electron paramagnetic resonance , chromatography , stereochemistry , medicine , physics , biology , nuclear physics , microbiology and biotechnology , quantum mechanics , fishery
Induction of iron overload in mice using 1% (w/w) dietary carbonyl iron resulted in marked decreases in 2 H and 31 P NMR relaxation times. Natural‐abundance deuterium ( 2 H) NMR spectroscopy has been used to measure 2 H T 1 values in vivo in the presence of body paramagnetic iron. This procedure offers a method for noninvasive determination of body iron stores. © 1987 Academic Press, Inc.