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1 H NMR studies of urine during fasting: Excretion of ketone bodies and acetylcarnitine
Author(s) -
Bales John R.,
Bell Jimmy D.,
Nicholson Jeremy K.,
Sadler Peter J.
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030605
Subject(s) - ketone bodies , excretion , urine , chemistry , acetylcarnitine , sarcosine , ketone , endocrinology , medicine , acetone , metabolism , biochemistry , biology , glycine , organic chemistry , amino acid
High‐resolution 1 H NMR spectroscopy has been applied to a study of urine from five normal human subjects during a 48‐h period of fasting and for 22 h thereafter. The excretion rates of all three ketone bodies (acetoacetate, 3‐ D ‐hydroxybutyrate, and acetone), acetylcaritine, and sarcosine during this period were measured. Parallel increases in the excretion of the ketone bodies and acetylcarnitine were observed during fasting with little change in the output of creatinine and sarcosine. © 1986 Academic Press, Inc.