Premium
Gd(DOTA): An alternative to Gd(DTPA) as a T 1,2 relaxation agent for NMR imaging or spectroscopy
Author(s) -
Magerstädt Michael,
Gansow Otto A.,
Brechbiel Martin W.,
Colcher David,
Baltzer Lars,
Knop Richard H.,
Girton Mary E.,
Naegele Matthias
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030517
Subject(s) - dota , gadolinium , diethylenetriaminepentaacetic acid , chemistry , chelation , nuclear magnetic resonance spectroscopy , mri contrast agent , in vivo , nuclear magnetic resonance , relaxation (psychology) , nuclear chemistry , lanthanide , pentetic acid , radiochemistry , stereochemistry , inorganic chemistry , medicine , organic chemistry , ion , physics , microbiology and biotechnology , biology
Methods have been devised for obtaining gadolinium(III) complexes of the ligands NOTA (1, 4, 7‐triazacyclononane‐ N , N ′, N ″‐triacetic acid), DOTA (1, 4, 7, 10‐tetraazacyclododecane‐ N , N ′, N ″, N ‴‐tetraacetic acid), TETA (1,4,8,11‐tetraazacyclotetradecane‐ N , N ′, N ″, N ‴‐tetraacetic acid), and DTPA (diethylenetriaminepentaacetic acid) as solids for use as pharmaceuticals. Their effectiveness as in vitro and in vivo contrast agents for NMR imaging or T 1,2 relaxation agents for spectroscopy has been investigated. The Gd(DOTA) complex was shown to be a more stable alternative to Gd(DTPA) by serum stability studies and measurement of stability constants. Images of tumors grown in athymic mice were obtained by NMR after injection of Gd(DOTA) and Gd(DTPA). © 1986 Academic Press, Inc.