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Pulse techniques for the suppression of individual components in multiexponential relaxation curves
Author(s) -
Metz Kenneth R.,
Stankiewicz Paul J.,
Sassani Joseph W.,
Briggs Richard W.
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030411
Subject(s) - relaxation (psychology) , spin–lattice relaxation , nuclear magnetic resonance , pulse (music) , exponential function , biological system , pulse sequence , in vivo , chemistry , chemical physics , aqueous solution , spin–spin relaxation , materials science , analytical chemistry (journal) , chromatography , physics , optics , mathematics , psychology , social psychology , mathematical analysis , detector , biology , nuclear quadrupole resonance , microbiology and biotechnology
NMR pulse sequences have been investigated which selectively suppress undesired signal components from multiple‐exponential spin‐spin and spin‐lattice relaxation curves. Suppression is achieved by exploiting differences in the relaxation times of sample components. Special attention is devoted to discussion of practical details necessary for implementation of these methods, as well as their relative advantages and disadvantages. The techniques are illustrated using multiple‐compartment aqueous phantoms and are then employed in measurements of proton T 1 and T 2 values for freshly isolated guinea pig lenses immersed in aqueous buffer solutions to prevent dehydration and maintain viability. These methods obviate many of the difficulties inherent in obtaining accurate relaxation times for minor components of multiple‐exponential curves and should be useful in many applications of NMR to the study of intact tissue, both in vitro and in vitro . © 1986 Academic Press, Inc.