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Monoclonal antibodies labeled with polymeric paramagnetic ion chelates
Author(s) -
Shreve Paul,
Aisen Alex M.
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030220
Subject(s) - paramagnetism , monoclonal antibody , chelation , chemistry , ion , covalent bond , antibody , relaxation (psychology) , in vitro , molecule , biochemistry , inorganic chemistry , immunology , biology , organic chemistry , physics , quantum mechanics , neuroscience
Polymeric paramagnetic ion chelate molecules were synthesized and covalently linked to monoclonal antibodies. The labeled antibodies retained their antigen binding capacity in vitro while carrying up to an average of 50 paramagnetic ion chelates, enabling specifically bound antibody concentrations less than 2.0 μ M to significantly reduce proton longitudinal relaxation times. © 1986 Academic Press, Inc.