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Ferromagnetic contrast agents: A new approach
Author(s) -
Renshaw Perry F.,
Owen Charles S.,
McLaughlin Alan C.,
Frey Terrence G.,
Leigh John S.
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030205
Subject(s) - paramagnetism , ferromagnetism , contrast (vision) , nuclear magnetic resonance , relaxation (psychology) , gastrointestinal tract , materials science , magnetite , chemistry , phase (matter) , condensed matter physics , computer science , medicine , physics , metallurgy , artificial intelligence , biochemistry , organic chemistry
Most contrast agents used in NMR imaging studies to date have been paramagnetic. However, it is also possible to obtain selective contrast with a ferromagnetic agent, and these agents are potentially more sensitive than paramagnetic compounds because of their large magnetic moments. The water relaxation ability of ferromagnetic, albumin‐coated magnetite (Fe 3 O 4 ) particles has been investigated. These particles are quite effective at reducing both T 1 and T 2 at relatively low particle concentrations. The potential applications of these particles include improved visualization of the liver, gastrointestinal tract, and genitourinary tract, as well as specific targeting and detection of small tumors or other cells with unique surface receptors. © 1986 Academic Press, Inc.