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Hypoxia‐sensitive NMR contrast agents
Author(s) -
Swartz Harold M.,
Chen Kai,
Pals Mark,
Sentjurc Marjeta,
Morse Philip D.
Publication year - 1986
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910030126
Subject(s) - hypoxia (environmental) , in vivo , chemistry , ischemia , contrast (vision) , oxygen , medicine , cardiology , biology , computer science , organic chemistry , microbiology and biotechnology , artificial intelligence
The rate of reduction of nitroxides is shown to be more rapid in hypoxic cells. The rate of reduction and the effect of hypoxia on the reduction rate vary for different nitroxides. These findings indicate that it may be feasible to develop in vivo NMR contrast agents that selectively will indicate areas of hypoxia and thereby aid in the detection of disease processes such as neoplasia, ischemia, and inflammation. © 1986 Academic Press, Inc.