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NMR compartmentalization of free water in the perfused rat heart
Author(s) -
Mauss Y.,
Grucker D.,
Fornasiero D.,
Chambron J.
Publication year - 1985
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1910020302
Subject(s) - compartmentalization (fire protection) , extracellular , chemistry , relaxation (psychology) , intracellular , nuclear magnetic resonance , spin–lattice relaxation , compartment (ship) , perfusion , biophysics , analytical chemistry (journal) , physics , chromatography , biochemistry , biology , enzyme , medicine , oceanography , nuclear quadrupole resonance , geology
Spin‐lattice ( T 1 ) and spin‐spin ( T 2 ) relaxation times have been measured on perfused rat hearts under two experimental conditions. T 1 exhibits a monoexponential decay. On the other hand T 2 has a decay with two components: a short one T 2s and a long one T 21 . These facts have been discussed according to cross‐relaxation and a bicompartmen‐talization of tissue assuming a slow exchange model for spin‐spin relaxation and a fast exchange model for spin‐lattice relaxation. Increasing the osmotic pressure of the perfusion solution decreased the absolute density proton of the T 2s compartment reflecting the loss of its water content. The paramagnetic ion manganese diminishes the values of T 1 and those of the long component T 21 without affceting its short component. Therefore the short component could be assigned to intracellular and the long component to extracellular free water. The extracellular T 2 (459 ms) is approximatively 10‐fold higher than the intracellular T 2 (45 ms) With images of “pure T 2 ” such a difference could be useful to enhance the contrast between organs and the surrounding liquid or between organs with different water compartmentalization.