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In vivo water quantification in mouse brain at 9.4 Tesla in a vasogenic edema model
Author(s) -
Schwarcz Attila,
Berente Zoltán,
Ősz Erzsébet,
Dóczi Tamás
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1324
Subject(s) - in vivo , brain edema , nuclear magnetic resonance , chemistry , edema , cold injury , pathology , nuclear medicine , biomedical engineering , medicine , biology , physics , microbiology and biotechnology , horticulture
The aim of our study was to establish a simple in vivo method for water quantification in vasogenic edema, and provide data on imaging of mouse brain at 9.4 Tesla. Apparent T 1 and spin density values determined by MRI were found to strongly correlate with the gravimetric water content of mouse brain undergoing cold injury. Using a two‐point calibration line between the spin density values for pure water and cortex of mouse brain, as well as the corresponding water contents in vivo, water could be quantified with satisfactory accuracy. Magn Reson Med 46:1246–1249, 2001. © 2001 Wiley‐Liss, Inc.