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In vivo 1 H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively‐coupled chronically implanted RF coil
Author(s) -
Silver X.,
Ni W. Xu,
Mercer E.V.,
Beck B.L.,
Bossart E.L.,
Inglis B.,
Mareci T.H.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1319
Subject(s) - electromagnetic coil , nuclear magnetic resonance , radiofrequency coil , spinal cord , chemistry , magnetic resonance imaging , materials science , physics , radiology , medicine , quantum mechanics , psychiatry
An inductively coupled, chronically implanted short‐solenoid coil was used to obtain in vivo localized 1 H NMR spectra and diffusion‐weighted images from a rat spinal cord. A 5 × 8 mm two‐turn elliptically shaped solenoid coil was implanted in rats at the site of a T‐12 vertebral‐level laminectomy. Excitation was achieved solely by a 3 × 3 cm external surface coil, and signal detection was achieved by inductively coupling the external coil to the implanted coil. The image signal‐to‐noise ratio (SNR) obtained with the inductively‐coupled implanted coil was compared with that obtained using a linear or a quadrature external surface coil. The implanted coil provided a gain by over a factor of 3 in SNR. The implanted coil was used to measure localized 1 H spectra in vivo at the T13/L1 spinal‐cord level within a 1.85 × 1.85 × 4.82 mm (16.5 μL) volume. With 256 averages, a ∼3‐s repetition delay and respiratory gating, a high‐quality spectrum was acquired in 13 min. In addition, water translational diffusion was measured in three orthogonal directions using a stimulated‐echo imaging sequence, with a short echo time (TE), to produce a quantitative map of diffusion in a rat spinal cord in vivo. Magn Reson Med 46:1216–1222, 2001. © 2001 Wiley‐Liss, Inc.