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Comparison of quantitative T 2 mapping and diffusion‐weighted imaging in the normal and pathologic prostate
Author(s) -
Gibbs Peter,
Tozer Daniel J.,
Liney Gary P.,
Turnbull Lindsay W.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1298
Subject(s) - prostate , effective diffusion coefficient , nuclear magnetic resonance , diffusion mri , diffusion , anisotropy , spin echo , relaxation (psychology) , peripheral , prostate gland , nuclear medicine , chemistry , magnetic resonance imaging , medicine , radiology , physics , optics , cancer , thermodynamics
In this study, diffusion‐weighted images of the human prostate were successfully obtained, enabling quantification of apparent diffusion coefficients (ADCs) in normal and pathologic regions. A dual acquisition fast spin‐echo sequence was used for accurate T 2 calculation. T 2 values were significantly higher in the peripheral zone than the central gland ( P = 0.015). No significant correlations were found in either normal or pathologic tissue between ADC values and relaxation rates for all three gradient directions and the orientationally averaged water diffusion coefficient. Evidence suggesting that diffusional anisotropy is present in normal prostatic tissue is also detailed, with significant differences noted between the z‐component and both the x‐ and y‐components of the ADC for peripheral zone ( P < 0.040) and central gland ( P < 0.001). Magn Reson Med 46:1054–1058, 2001. © 2001 Wiley‐Liss, Inc.