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4D deformation modeling of cortical disease progression in Alzheimer's dementia
Author(s) -
Janke Andrew L.,
Zubicaray Greig de,
Rose Stephen E.,
Griffin Mark,
Chalk Jonathan B.,
Galloway Graham J.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1243
Subject(s) - entorhinal cortex , atrophy , voxel , dementia , cortex (anatomy) , hippocampus , neuroscience , alzheimer's disease , cerebral cortex , disease , medicine , psychology , pathology , radiology
This work describes the development of a model of cerebral atrophic changes associated with the progression of Alzheimer's disease (AD). Linear registration, region‐of‐interest analysis, and voxel‐based morphometry methods have all been employed to elucidate the changes observed at discrete intervals during a disease process. In addition to describing the nature of the changes, modeling disease‐related changes via deformations can also provide information on temporal characteristics. In order to continuously model changes associated with AD, deformation maps from 21 patients were averaged across a novel z ‐score disease progression dimension based on Mini Mental State Examination (MMSE) scores. The resulting deformation maps are presented via three metrics: local volume loss (atrophy), volume (CSF) increase, and translation (interpreted as representing collapse of cortical structures). Inspection of the maps revealed significant perturbations in the deformation fields corresponding to the entorhinal cortex (EC) and hippocampus, orbitofrontal and parietal cortex, and regions surrounding the sulci and ventricular spaces, with earlier changes predominantly lateralized to the left hemisphere. These changes are consistent with results from post‐mortem studies of AD. Magn Reson Med 46:661–666, 2001. © 2001 Wiley‐Liss, Inc.