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In vivo hyperpolarized 129 Xe NMR spectroscopy in tumors
Author(s) -
Wolber Jan,
McIntyre Dominick J.O.,
Rodrigues Loreta M.,
Carnochan Paul,
Griffiths John R.,
Leach Martin O.,
Bifone Angelo
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1231
Subject(s) - in vivo , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , isotopes of xenon , chemistry , xenon , hyperpolarization (physics) , relaxation (psychology) , spin–lattice relaxation , spectroscopy , nmr spectra database , spectral line , physics , medicine , quantum mechanics , astronomy , nuclear quadrupole resonance , biology , microbiology and biotechnology , organic chemistry
The first in vivo hyperpolarized 129 Xe NMR study in experimental tumors is presented. Hyperpolarized 129 Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The 129 Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. © 2001 Wiley‐Liss, Inc.