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Nuclear magnetic relaxation dispersion of ferritin and ferritin‐like magnetic particle solutions: A pH‐effect study
Author(s) -
Gossuin Yves,
Roch Alain,
Lo Bue Francesco,
Muller Robert N.,
Gillis Pierre
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1216
Subject(s) - ferritin , proton , relaxation (psychology) , chemistry , dispersion (optics) , nuclear magnetic resonance , akaganéite , magnetic relaxation , particle (ecology) , magnetic field , analytical chemistry (journal) , magnetization , physics , chromatography , nuclear physics , psychology , social psychology , biochemistry , oceanography , adsorption , quantum mechanics , optics , goethite , geology
The relaxation mechanism of water protons in the presence of ferritin is still being debated. In this work, the pH dependence of the relaxation induced by ferritin and Fercayl®, a ferritin‐like akaganeite particle, is studied through T 1 and T 2 nuclear magnetic relaxation dispersion (NMRD) profiles. To differing extents, the relaxation brought about by both systems is significantly affected by pH. A proton exchange time of 33 ns (at pH 6 and 37°C) is deduced from the fittings of Fercayl® T 1 NMRD profiles. The linearity of the relationship between 1/ T 2 and the magnetic field B 0 for ferritin and Fercayl® solutions is not altered by changes in pH. The parameters of this linearity strongly depend on pH for the latter, while remaining unchanged for the former. These results are interpreted in terms of an exchange between protons belonging to hydroxyl groups at the surface of the particle and bulk water protons. Magn Reson Med 46:476–481, 2001. © 2001 Wiley‐Liss, Inc.