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Optimal dose of Gd‐DTPA in dynamic MR studies
Author(s) -
Rusinek Henry,
Lee Vivian S.,
Johnson Glyn
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1193
Subject(s) - renal function , random error , nuclear medicine , relaxation (psychology) , nuclear magnetic resonance , gadolinium , range (aeronautics) , mathematics , chemistry , materials science , physics , medicine , statistics , composite material , organic chemistry
The relationship between the administered dose d of Gd‐DTPA and the accuracy of measurements of the glomerular filtration rate G and the cardiac output O was investigated. For a wide range of values the concentration of Gd‐DTPA can be uniquely derived from MR signals and precontrast longitudinal relaxation time. Fixed and random errors in these measured variables were analyzed. Depending on noise level and the level of renal function, errors in G reach a minimum for d = 1.4–2.8 mmol. Random errors in G are relatively insensitive to d as long as d > 1.5 mmol. These results establish the feasibility of dynamic MR measurements using doses of Gd‐DTPA that are several times lower than current standards. Magn Reson Med 46:312–316, 2001. © 2001 Wiley‐Liss, Inc.