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Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin‐labeled MRI
Author(s) -
Hendrich Kristy S.,
Kochanek Patrick M.,
Melick John A.,
Schiding Joanne K.,
Statler Kimberly D.,
Williams Donald S.,
Marion Donald W.,
Ho Chien
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1178
Subject(s) - isoflurane , pentobarbital , fentanyl , barbiturate , anesthetic , anesthesia , cerebral blood flow , perfusion , medicine , chemistry , cardiology
The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin‐labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5–3 times lower in most regions analyzed during anesthesia with either fentanyl (with N 2 O/O 2 ) or pentobarbital vs. isoflurane (with N 2 O/O 2 ), in agreement with findings utilizing invasive measurement techniques. CBF was heterogeneous in rats anesthetized with isoflurane (with N 2 O/O 2 ), but relatively homogeneous in rats anesthetized with either fentanyl (with N 2 O/O 2 ) or pentobarbital, also in agreement with studies using other techniques. Magn Reson Med 46:202–206, 2001. © 2001 Wiley‐Liss, Inc.