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Improved perfusion quantification in FAIR imaging by offset correction
Author(s) -
Sidaros Karam,
Andersen Irene K.,
Gesmar Henrik,
Rostrup Egill,
Larsson Henrik B.W.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1176
Subject(s) - imaging phantom , perfusion , nuclear magnetic resonance , perfusion scanning , materials science , offset (computer science) , spins , scanner , slab , arterial spin labeling , biomedical engineering , physics , optics , computer science , medicine , radiology , condensed matter physics , programming language , geophysics
Perfusion quantification using pulsed arterial spin labeling has been shown to be sensitive to the RF pulse slice profiles. Therefore, in Flow‐sensitive Alternating‐Inversion Recovery (FAIR) imaging the slice selective (ss) inversion slab is usually three to four times thicker than the imaging slice. However, this reduces perfusion sensitivity due to the increased transit delay of the incoming blood with unperturbed spins. In the present article, the dependence of the magnetization on the RF pulse slice profiles is inspected both theoretically and experimentally. A perfusion quantification model is presented that allows the use of thinner ss inversion slabs by taking into account the offset of RF slice profiles between ss and nonselective inversion slabs. This model was tested in both phantom and human studies. Magn Reson Med 46:193–197, 2001. © 2001 Wiley‐Liss, Inc.