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External standard method for the in vivo quantification of choline‐containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla
Author(s) -
Bakken Inger J.,
Gribbestad Ingrid S.,
Singstad Trond E.,
Kvistad Kjell A.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1175
Subject(s) - choline , phosphocholine , in vivo , malignancy , in vivo magnetic resonance spectroscopy , breast cancer , imaging phantom , nuclear medicine , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chemistry , medicine , cancer , pathology , magnetic resonance imaging , radiology , biology , biochemistry , physics , phospholipid , microbiology and biotechnology , membrane , phosphatidylcholine
Quantification of choline‐containing compounds observed with 1 H MRS of breast tumors is of interest since such compounds have been linked to malignancy. Experiments were performed at 1.5 T with an external standard containing phosphocholine for calibration. In phantom studies, good precision was achieved after correction for T 1 / T 2 effects. T 2 values for choline were estimated for two breast cancer patients. A choline concentration of 2.0 mM was calculated for a third patient, a result comparable to in vitro findings. Magn Reson Med 46:189–192, 2001. © 2001 Wiley‐Liss, Inc.