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Proton magnetic resonance spectroscopy of Sjögren‐Larsson syndrome heterozygotes
Author(s) -
Kaminaga Tatsuro,
Mano Toshiyuki,
Ono Jiro,
Kusuoka Hideo,
Nakamura Hironobu,
Nishimura Tsunehiko
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1146
Subject(s) - heterozygote advantage , compound heterozygosity , chemistry , proton magnetic resonance , nuclear magnetic resonance , medicine , biochemistry , allele , physics , gene
Abstract A deficit of fatty alcohol:NAD + oxidoreductase complex (FAO) activity has been detected in patients with the Sjögren‐Larsson syndrome (SLS). A moderate decrease in FAO activity has also been reported in heterozygote SLS subjects. Abnormal peaks were detected with proton magnetic resonance spectroscopy ( 1 H‐MRS) in homozygote SLS subjects. The purpose of this study was to examine whether 1 H‐MRS can be used to detect metabolic and/or pathological abnormalities in heterozygote SLS subjects. Four SLS heterozygotes were examined using 1 H‐MRS. A moderate decrease in FAO activity was demonstrated in two of the four heterozygotes. Abnormal peaks were detected at 0.9 ppm in the spectrum from cerebral hemispheres of every heterozygote. 1 H‐MRS was able to detect an abnormal accumulation of fatty alcohols and lipids, which is expected to increase due to an decrease in FAO activity or dysmyelination in heterozygote SLS subjects. Thus, 1 H‐MRS is suggested to be a powerful tool in the screening of SLS heterozygotes. Magn Reson Med 45:1112–1115, 2001. © 2001 Wiley‐Liss, Inc.