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Dynamic contrast‐enhanced MRI using Gd‐DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors
Author(s) -
Port Ruediger E.,
Knopp Michael V.,
Brix Gunnar
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1137
Subject(s) - interquartile range , nuclear medicine , dynamic contrast , kinetics , medicine , population , dynamic contrast enhanced mri , magnetic resonance imaging , chemistry , radiology , physics , environmental health , quantum mechanics
Gd‐DTPA kinetics in arterial blood was investigated by dynamic MRI in 47 patients with malignant and benign mammary tumors. Signal enhancement was monitored for 10 min after the beginning of a 1‐min infusion of 0.1 mmol/kg Gd‐DTPA. Kinetics in blood was biexponential with median half‐lives of 21 sec and 11.1 min, respectively. Peak signal enhancement and the area under the signal enhancement–time curve varied 2.5‐ and 3.7‐fold between patients. The shortest mean residence time in one of up to three tumor compartments, MRT *, was estimated using either the individual (reference) or a mean population (surrogate) arterial input function (AIF). MRT * (reference estimate) was 1.0 (0–1.5), 1.9 (1.5–2.3), and 2.5 (2.3–2.8) min in carcinomas, fibroadenomas, and mastopathies, respectively (median and interquartile distance). Surrogate estimates were unbiased but differed from the reference estimates 1.5‐fold or more in 23% of cases. AIFs should be monitored individually if accurate estimates of individual MRT * are desired. Magn Reson Med 45:1030–1038, 2001. © 2001 Wiley‐Liss, Inc.