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MRI mapping of cerebrovascular reactivity using square wave changes in end‐tidal PCO 2
Author(s) -
Vesely Alex,
Sasano Hiroshi,
Volgyesi George,
Somogyi Ron,
Tesler Janet,
Fedorko Ludwik,
Grynspan Jonathan,
Crawley Adrian,
Fisher Joseph A.,
Mikulis David
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1134
Subject(s) - pco2 , white matter , carbon dioxide , nuclear magnetic resonance , reactivity (psychology) , cardiology , medicine , chemistry , nuclear medicine , magnetic resonance imaging , anesthesia , physics , radiology , pathology , alternative medicine , organic chemistry
Cerebrovascular reactivity can be quantified by correlating blood oxygen level dependent (BOLD) signal intensity with changes in end‐tidal partial pressure of carbon dioxide (PCO 2 ). Four 3‐min cycles of high and low PCO 2 were induced in three subjects, each cycle containing a steady PCO 2 level lasting at least 60 sec. The BOLD signal closely followed the end‐tidal PCO 2 . The mean MRI signal intensity difference between high and low PCO 2 (i.e., cerebrovascular reactivity) was 4.0 ± 3.4% for gray matter and 0.0 ± 2.0% for white matter. This is the first demonstration of the application of a controlled reproducible physiologic stimulus, i.e., alternating steady state levels of PCO 2 , to the quantification of cerebrovascular reactivity. Magn Reson Med 45:1011–1013, 2001. © 2001 Wiley‐Liss, Inc.
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