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Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology
Author(s) -
Turetschek Karl,
Floyd Eugenia,
Shames David M.,
Roberts Timothy P.L.,
Preda Anda,
Novikov Viktor,
Corot Claire,
Carter Wayne O.,
Brasch Robert C.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1117
Subject(s) - microvessel , albumin , contrast (vision) , pathology , vascular permeability , chemistry , histopathology , breast tumor , nuclear medicine , medicine , breast cancer , immunohistochemistry , cancer , computer science , artificial intelligence
The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW = 6.47 kDa) for the MR assessment of microvessel characteristics was assessed in 42 chemically‐induced breast tumors, with comparisons to albumin‐(Gd‐DTPA). Microvessel characteristics, including the transendothelial permeability (K PS ) and the fractional blood volume (fPV), were estimated by using dynamic MR data fit to a bidirectional two‐compartment model. The MR‐derived estimates for K PS and fPV using each contrast agent were compared, and assays using each contrast agent were correlated to the histologic tumor grade (SBR score) and the microvascular density (MVD) counts. Using P792‐enhanced data, neither K PS nor fPV showed a statistically significant correlation with the tumor grade or the MVD ( P > .05). Conversely, using albumin‐(GdDTPA) 30 , K PS values correlated significantly with the histologic tumor grade (r = .55; P < .0005) and the MVD (r = .34, P < .05), whereas no correlation was established for fPV. In conclusion, based on P792 data no correlation between tumor microvascular characteristics and histologic markers (SBR score or MVD) was found in this breast tumor model. Our analysis suggests that contrast media of relatively large (on the order of 90 kDa) molecular size, such as albumin‐(GdDTPA) 30 , are more accurate for the characterization of tumor microvessels. Magn Reson Med 45:880–886, 2001. © 2001 Wiley‐Liss, Inc.