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Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo
Author(s) -
Trabesinger Andreas H.,
Boesiger Peter
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1094
Subject(s) - coherence (philosophical gambling strategy) , in vivo , glutathione , chemistry , quantum , pulse (music) , selectivity , nuclear magnetic resonance , physics , optics , biochemistry , biology , quantum mechanics , microbiology and biotechnology , detector , enzyme , catalysis
Abstract An improved double quantum coherence (DQC) filter for the selective in vivo detection of glutathione (GSH) in the human brain at 1.5 Tesla is presented. The goal was to minimize contamination of the DQC‐filtered GSH signal at 2.9 ppm with contributions arising from GABA. The modification consists of tailoring the frequency response of the read pulse, which converts DQC into anti‐phase single quantum coherence in such a way that the GABA β and γ resonances at 3.0 and 1.9 ppm, respectively, remain unaffected. An implementation incorporating a Dante pulse train is used for in vitro tests as well as for in vivo applications. Magn Reson Med 45:708–710, 2001. © 2001 Wiley‐Liss, Inc.