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Dynamic 19 F‐MRI of pulmonary ventilation using sulfur hexafluoride (SF 6 ) gas
Author(s) -
Schreiber Wolfgang Günther,
Eberle Balthasar,
LaukemperOstendorf Simone,
Markstaller Klaus,
Weiler Norbert,
Scholz Alexander,
Bürger Katja,
Heussel Claus Peter,
Thelen Manfred,
Kauczor HansUlrich
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.1082
Subject(s) - sulfur hexafluoride , tidal volume , ventilation (architecture) , nuclear medicine , chemistry , volume (thermodynamics) , nuclear magnetic resonance , medicine , respiratory system , physics , thermodynamics , organic chemistry , quantum mechanics
A new method for dynamic imaging of pulmonary wash‐in and wash‐out kinetics of inhaled sulfur hexafluoride (SF 6 ) gas was developed. Measurements at the fluorine‐19 Larmor frequency were performed in pigs using a gradient echo pulse sequence with 0.5 ms echo time and a measurement time of 9.1 s per image. Dynamic MRI was performed during wash‐in and wash‐out of SF 6 gas in mechanically ventilated porcine lungs. A postprocessing strategy was developed for quantitative determination of wash‐out time constants in the presence of noise. Mean wash‐out constants were 4.78 ± 0.48 breaths vs. 4.33 ± 0.76 breaths for left and right lung when ventilation was performed with low tidal volume, and 1.73 ± 0.16 breaths vs. 1.85 ± 0.11 breaths with high tidal volume ventilation. In conclusion, breath‐hold MRI of SF 6 gas is feasible in large animals. Moreover, regional wash‐in and wash‐out kinetics of SF 6 can be determined noninvasively with this new method. Potential human applications are discussed. Magn Reson Med 45:605–613, 2001. © 2001 Wiley‐Liss, Inc.