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In vivo quantification of choline compounds in the breast with 1 H MR spectroscopy
Author(s) -
Bolan Patrick J.,
Meisamy Sina,
Baker Eva H.,
Lin Joseph,
Emory Timothy,
Nelson Michael,
Everson Lenore I.,
Yee Douglas,
Garwood Michael
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10654
Subject(s) - in vivo , choline , nuclear magnetic resonance , spectroscopy , in vivo magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , chemistry , nuclear medicine , magnetic resonance imaging , medicine , physics , biology , radiology , biochemistry , microbiology and biotechnology , quantum mechanics
This work describes a methodology for quantifying levels of total choline‐containing compounds (tCho) in the breast using in vivo 1 H MR spectroscopy (MRS) at high field (4 Tesla). Water is used as an internal reference compound to account for the partial volume of adipose tissue. Peak amplitudes are estimated by fitting one peak at a time over a narrow frequency band to allow measurement of small metabolite resonances in spectra with large lipid peaks. This quantitative method significantly improves previously reported analysis methods by accounting for the variable sensitivity of breast 1 H MRS measurements. Using this technique, we detected and quantified a tCho peak in 214 of 500 in vivo spectra. tCho levels were found to be significantly higher in malignancies than in benign abnormalities and normal breast tissues, which suggests that this technique could be used to diagnose suspicious lesions and monitor response to cancer treatments. Magn Reson Med 50:1134–1143, 2003. © 2003 Wiley‐Liss, Inc.