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New hybrid technique for accurate and reproducible quantitation of dynamic contrast‐enhanced MRI data
Author(s) -
Li KaLoh,
Jackson Alan
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10652
Subject(s) - monte carlo method , dynamic contrast enhanced mri , contrast (vision) , computer science , dynamic contrast , algorithm , magnetic resonance imaging , mathematics , artificial intelligence , radiology , statistics , medicine
The accuracy and precision of two major approaches for analyzing dynamic MRI data from the first passage of a Gd‐DTPA contrast bolus are examined, using a Monte Carlo simulation. Method 1 fits the contrast concentration curve of the first pass to a two‐compartment kinetic model to determine the tissue pharmacokinetic parameters. Method 2 decomposes intravascular and interstitial components of the first‐pass curve based on a leakage profile (LP) model. Based on the results of these Monte Carlo simulations, a new “hybrid” method is proposed that combines both analytical approaches to optimize accuracy and precision of estimates of K trans , v e , and v p . The new method was evaluated by computer simulation and used on experimental results from a patient with primary brain tumors. The new method has the potential to provide more accurate quantification of tissue plasma volume and vessel permeability. Magn Reson Med 50:1286–1295, 2003. © 2003 Wiley‐Liss, Inc.