Premium
Investigation of the microstructure of the isolated rat heart: A comparison between T * 2 ‐ and diffusion‐weighted MRI
Author(s) -
Köhler Sascha,
Hiller KarlHeinz,
Waller Christiane,
Bauer Wolfgang R.,
Haase Axel,
Jakob Peter M.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10636
Subject(s) - dephasing , diffusion mri , high resolution , diffusion , fiber , resolution (logic) , microstructure , nuclear magnetic resonance , short axis , materials science , physics , nuclear medicine , chemistry , magnetic resonance imaging , mathematics , crystallography , computer science , long axis , medicine , geometry , condensed matter physics , radiology , artificial intelligence , thermodynamics , remote sensing , geology , composite material
Myocardial fiber structure can be determined with diffusion‐weighted (DW) MRI as well as with high‐resolution T * 2 imaging. The purpose of the present study was twofold: to provide a more quantitative description of T * 2 ‐based myocardial fiber contrast, and to compare the T * 2 ‐based fiber structure with high‐resolution (78 μm in‐plane, 1‐mm slice thickness) DW images of the isolated rat heart at 11.75 T. This study demonstrates that the static dephasing regime is responsible for visualization of myocardial microstructure, and that the dynamic dephasing regime can be neglected. In comparison with DW experiments, T * 2 mapping and DW images yield almost equivalent information on myocardial fiber structure. Magn Reson Med 50:1144–1150, 2003. © 2003 Wiley‐Liss, Inc.