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Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer
Author(s) -
Ward Kathleen,
Schussheim Adam E.,
Balaban Robert S.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10625
Subject(s) - magnetization transfer , magnetization , proton , mitochondrion , nuclear magnetic resonance , chemistry , cardiac muscle , biophysics , anatomy , physics , biology , biochemistry , magnetic field , medicine , magnetic resonance imaging , nuclear physics , radiology , quantum mechanics
The contribution of mitochondria to water‐macromolecule proton magnetization transfer (MT) was evaluated in porcine heart tissue. An examination of isolated mitochondria in suspension, at the same concentration as found in heart tissue, revealed MT effects very similar in magnitude and bandwidth to those in intact heart tissue. Disruption of the gross structure of the mitochondria by freeze‐thawing or with detergent resulted in only ∼25% decreases in MT, which suggests that the structure of the mitochondria is not critical for these effects. The current data indicate that mitochondria macromolecules contribute significantly to MT in the intact heart. Magn Reson Med 50:1312–1316, 2003. Published 2003 Wiley‐Liss, Inc.