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Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data
Author(s) -
Wilke M.,
Schmithorst V.J.,
Holland S.K.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10606
Subject(s) - spatial normalization , a priori and a posteriori , neuroimaging , computer science , normalization (sociology) , data set , normative , artificial intelligence , medicine , data mining , psychology , neuroscience , philosophy , epistemology , voxel , sociology , anthropology
Spatial normalization and morphological studies of pediatric brain imaging data based on adult reference data may not be appropriate due to the developmental differences between the two populations. In this study, we set out to create pediatric templates and a priori brain tissue data from a large collection of normal, healthy children to compare it to standard adult data available within a widely used imaging software solution (SPM99, WDOCN, London, UK). Employing four different processing strategies, we found considerable differences between our pediatric data and the adult data. We conclude that caution should be used when analyzing pediatric brain data using adult a priori information. To assess the effects of using pediatric a priori brain information, the data obtained in this study is available to the scientific community from our website ( www.irc.cchmc.org ). Magn Reson Med 50:749–757, 2003. © 2003 Wiley‐Liss, Inc.