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Dynamic 3 He imaging for quantification of regional lung ventilation parameters
Author(s) -
Dupuich David,
Berthezène Yves,
Clouet PierreLouis,
Stupar Vasile,
Canet Emmanuelle,
Crémillieux Yannick
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10590
Subject(s) - ventilation (architecture) , nuclear medicine , lung , biomedical engineering , dynamic imaging , methacholine , materials science , medicine , computer science , image processing , physics , respiratory disease , image (mathematics) , artificial intelligence , thermodynamics , digital image processing
Dynamic ventilation imaging using laser‐polarized 3 He has a promising potential for elucidating the physiology and physiopathology of the lungs. In this study, a methodological approach is proposed for the assessment and quantification of local ventilation parameters. High‐temporal‐resolution coronal ventilation image series were obtained with a projection‐reconstruction (PR) sequence combined with the sliding‐window technique. After image series were processed, parametric pixel‐by‐pixel maps of the gas arrival time, filling time constant, inflation rate, and gas volume were generated. The acquisition technique and the signal processing procedure, which are referred to collectively as sliding pulmonary imaging for respiratory overview (SPIRO), were tested in vivo in healthy rat lungs using a contrast media injector for controlled 3 He flow and volume injection in the animal lungs. The same protocol was applied to broncho‐constriction animal models using intravenous injection of methacholine solution. Inflation rate values measured in the lungs were found to decrease with increasing doses of injected methacholine solution. This study demonstrates that it is possible to obtain quantitative regional gas dynamic information using the SPIRO technique in a single polarized gas inspiration. Magn Reson Med 50:777–783, 2003. © 2003 Wiley‐Liss, Inc.