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Breathhold abdominal and thoracic proton MR spectroscopy at 3T
Author(s) -
KatzBrull Rachel,
Rofsky Neil M.,
Lenkinski Robert E.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10560
Subject(s) - thorax (insect anatomy) , abdomen , medicine , nuclear medicine , in vivo magnetic resonance spectroscopy , nuclear magnetic resonance , breathing , anatomy , magnetic resonance imaging , radiology , physics
The clinical utility of proton MR spectroscopy ( 1 H‐MRS) has been well demonstrated in the brain, prostate, and breast. The aims of this work were to investigate 1) the feasibility of abdominal and thoracic 1 H‐MRS at 3T, 2) the benefits of breathholding to MRS in these regions, and 3) the utility of multiple breathhold averaging for MRS. Breathholding either eliminated or markedly reduced phase and frequency shifts and outer voxel contamination that were associated with the motion of the abdomen and the thorax during breathing. Breathholding was found to be essential to spectroscopic investigation of the thorax. Spectra of renal cell carcinoma metastases in the abdomen and thorax were obtained utilizing multiple breathhold averaging. These spectra exhibited a resonance at 3.2 ppm attributed to the trimethylamine moiety of choline metabolites. The results of this study suggest a practical strategy for implementation of 1 H‐MRS in the body. Magn Reson Med 50:461–467, 2003. © 2003 Wiley‐Liss, Inc.