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Assessment and compensation of susceptibility artifacts in gradient echo MRI of hyperpolarized 3 He gas
Author(s) -
Wild Jim M.,
Fichele Stan,
Woodhouse Neil,
Paley Martyn N.J.,
Swift Andrew,
Kasuboski Larry,
van Beek Edwin J.R.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10549
Subject(s) - gradient echo , dephasing , signal (programming language) , nuclear magnetic resonance , echo (communications protocol) , spin echo , lung , nuclear medicine , magnetic resonance imaging , chemistry , biomedical engineering , physics , medicine , radiology , computer science , computer network , quantum mechanics , programming language
Abstract The effects of macroscopic background field gradients upon 2D gradient echo images of inhaled 3 He in the human lung were investigated at 1.5 T. Effective compensation of in‐slice signal loss in 3 He gradient echo images was then demonstrated using a multiple acquisition interleaved single gradient echo sequence. This method restores signal dephasing through a combination of separate images acquired with different slice refocusing gradients. In vivo imaging of volunteers with the sequence shows substantial restoration of signal at the lung periphery and close to blood vessels. The technique presented may be useful when using 3 He MRI for volumetric measurements of lung ventilation and in studies using 3 He combined with intravenous contrast as a means of assessing lung ventilation/perfusion (V/Q). Magn Reson Med 50:417–422, 2003. © 2003 Wiley‐Liss, Inc.