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Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging
Author(s) -
Ennis Daniel B.,
Epstein Frederick H.,
Kellman Peter,
Fananapazir Lameh,
McVeigh Elliot R.,
Arai Andrew E.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10543
Subject(s) - diastole , cardiac cycle , hypertrophic cardiomyopathy , cardiology , systole , medicine , cardiomyopathy , cardiac function curve , diastolic function , heart failure , blood pressure
Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volunteers (NVs) using MR tagging. A prospectively‐gated fast gradient‐echo sequence with an echo‐train readout was modified to support complementary spatial modulation of magnetization (CSPAMM) tagging and full cardiac cycle data acquisition using the cardiac phase to order reconstruction (CAPTOR), thus providing tag persistence and data acquisition during the entire cardiac cycle. Total systolic strains in FHC patients were significantly reduced in septal and inferior regions (both P < 0.01). Early‐diastolic strain rates were reduced in all regions of the FHC group (all P < 0.03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients. Magn Reson Med 50:638–642, 2003. Published 2003 Wiley‐Liss, Inc.