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MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
Author(s) -
Bulte Jeff W.M.,
BenHur Tamir,
Miller Bradley R.,
MizrachiKol Rachel,
Einstein Ophira,
Reinhartz Etti,
Zywicke Holly A.,
Douglas Trevor,
Frank Joseph A.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10511
Subject(s) - neurosphere , microscopy , pathology , magnetic resonance imaging , chemistry , nuclear magnetic resonance , neuroscience , biology , medicine , cellular differentiation , biochemistry , physics , radiology , adult stem cell , gene
Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high‐resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols. Magn Reson Med 50:201–205, 2003. © 2003 Wiley‐Liss, Inc.