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Evaluation of systematic quantification errors in velocity‐selective arterial spin labeling of the brain
Author(s) -
Duhamel Guillaume,
de Bazelaire Cédric,
Alsop David C.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10510
Subject(s) - subtraction , arterial spin labeling , perfusion , nuclear magnetic resonance , perfusion scanning , cerebral blood flow , biomedical engineering , chemistry , physics , nuclear medicine , mathematics , medicine , radiology , cardiology , arithmetic
Velocity‐selective (VS) sequences potentially permit arterial spin labeling (ASL) perfusion imaging with labeling applied very close to the tissue. In this study the effects of cerebrospinal fluid (CSF) motion, radiofrequency (RF) field imperfections, and sequence timing parameters on the appearance and quantitative perfusion values obtained with VS‐ASL were evaluated. Large artifacts related to CSF motion were observed with moderate velocity weighting, which were removed by inversion recovery preparation at the cost of increased imaging time. Imperfect refocusing and excitation pulses resulting from nonuniform RF fields produced systematic errors in the ASL subtraction images. A phase cycling scheme was introduced to eliminate these errors. Quantitative perfusion images were obtained with CSF suppression and phase cycling. Gray matter blood flow of 27.7 ml 100 g –1 min –1 , approximately half the value reported in studies using spatially‐selective ASL, was measured. Potential sources for this underestimation are discussed. Magn Reson Med 50:145–153, 2003. © 2003 Wiley‐Liss, Inc.