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Dynamic radial projection MRI of inhaled hyperpolarized 3 He gas
Author(s) -
Wild Jim M.,
Paley Martyn N.J.,
Kasuboski Larry,
Swift Andrew,
Fichele Stan,
Woodhouse Neil,
Griffiths Paul D.,
van Beek Edwin J.R.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10477
Subject(s) - undersampling , imaging phantom , image resolution , projection (relational algebra) , temporal resolution , diaphragm (acoustics) , physics , oversampling , nuclear magnetic resonance , biomedical engineering , nuclear medicine , materials science , computer science , optics , medicine , artificial intelligence , algorithm , acoustics , loudspeaker , optoelectronics , cmos
A radial projection sliding‐window sequence has been developed for imaging the rapid flow of 3 He gas in human lungs. The short echo time (TE) of the radial sequence lends itself to fast repetition times, and thus allows a rapid update in the image when it is reconstructed with a sliding window. Oversampling in the radial direction combined with angular undersampling can further reduce the time needed to acquire a complete image data set, without significantly compromising spatial resolution. Controlled flow phantom experiments using hyperpolarized 3 He gas exemplify the temporal resolution of the method. In vivo studies on three healthy volunteers, one patient with chronic obstructive pulmonary disease (COPD), and one patient with hemiparalysis of the right diaphragm demonstrate that it is possible to accurately resolve the passage of gas down the trachea and bronchi and into the peripheral lung. Magn Reson Med 49:991–997, 2003. © 2003 Wiley‐Liss, Inc.