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Optimized spiral imaging for measurement of myocardial T 2 relaxation
Author(s) -
Foltz Warren D.,
AlKwifi Osama,
Sussman Marshall S.,
Stainsby Jeff A.,
Wright Graham A.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10467
Subject(s) - standard deviation , spiral (railway) , relaxation (psychology) , residual , microcirculation , gold standard (test) , nuclear magnetic resonance , biomedical engineering , mathematics , computer science , physics , nuclear medicine , medicine , statistics , algorithm , mathematical analysis , radiology
Microcirculation oxygen levels and blood volumes should be reflected in measurements of myocardial T 2 relaxation. This work describes the optimization of a spiral imaging strategy for robust myocardial T 2 measurement to minimize the standard deviation of T 2 measurement (σ T 2 ). Theoretical and experimental studies of blurring at muscle/blood interfaces enabled the derivation of parameter sets which reduce σ T 2 to the level of 5%. T 2 relaxation mapping within healthy volunteers provided estimation of residual σ T 2 within the optimized technique. The standard deviation in T 2 measurement across regions of interest (ROIs) in different locations is about 9%. The standard deviation in T 2 measurement in an ROI across different time points is about 5%. Magn Reson Med 49:1089–1097, 2003. © 2003 Wiley‐Liss, Inc.