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High‐resolution in vivo CBV mapping with MRI in wild‐type mice
Author(s) -
Wu Ed X.,
Wong Kelvin K.,
Andrassy Martin,
Tang Haiying
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10425
Subject(s) - olfactory bulb , cerebral blood volume , nuclear magnetic resonance , chemistry , in vivo , magnetic resonance imaging , hippocampal formation , blood volume , nuclear medicine , central nervous system , medicine , biology , radiology , physics , microbiology and biotechnology
NMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild‐type mice. The CBV mapping was based on changes in the steady‐state NMR transverse relaxation rate (Δ R 2 ) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm × 100 μm × 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The Δ R 2 dosage dependency and MION tissue clearance in mouse are also reported. Magn Reson Med 49:765–770, 2003. © 2003 Wiley‐Liss, Inc.