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Imaging single mammalian cells with a 1.5 T clinical MRI scanner
Author(s) -
FosterGareau Paula,
Heyn Chris,
Alejski Andrew,
Rutt Brian K.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10417
Subject(s) - steady state free precession imaging , scanner , pulse sequence , computer science , tracking (education) , magnetic resonance imaging , electromagnetic coil , pulse (music) , nuclear magnetic resonance , biomedical engineering , artificial intelligence , physics , medicine , radiology , psychology , telecommunications , pedagogy , quantum mechanics , detector
In the present work, we demonstrate that the steady‐state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom‐built insertable gradient coil and customized RF coils can be used to detect individual SPIO‐labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single‐cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans. Magn Reson Med 49:968–971, 2003. © 2003 Wiley‐Liss, Inc.