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Indirect 17 O‐magnetic resonance imaging of cerebral blood flow in the rat
Author(s) -
Tailor Dharmesh R.,
Roy Arijit,
Regatte Ravinder R.,
Charagundla Sridhar R.,
McLaughlin Alan C.,
Leigh John S.,
Reddy Ravinder
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10403
Subject(s) - nuclear magnetic resonance , cerebral blood flow , magnetic resonance imaging , chemistry , washout , blood flow , nuclear medicine , temporal resolution , resolution (logic) , signal (programming language) , tracer , proton , analytical chemistry (journal) , physics , medicine , optics , chromatography , radiology , artificial intelligence , meteorology , computer science , nuclear physics , cardiology , programming language , quantum mechanics
Proton T 1ρ ‐dispersion MRI is demonstrated for indirect, in vivo detection of 17 O in the brain. This technique, which may be readily implemented on any clinical MRI scanner, is applied towards high‐resolution, quantitative mapping of cerebral blood flow (CBF) in the rat by monitoring the clearance of 17 O‐enriched water. Strategies are derived and employed for 1) quantitation of absolute H 2 17 O tracer concentration from a ratio of high‐ and low‐frequency spin‐locked T 1ρ images, and 2) mapping CBF without having to transform the T 1ρ signal to H 2 17 O tracer concentration. Absolute regional blood flow was mapped in a single 3‐mm brain slice at an in‐plane resolution of 0.4 × 0.8 mm within a 5‐min tracer washout time; these data are consistent with the less localized CBF measurements reported in the literature. T 1ρ ‐weighted imaging yields excellent signal‐to‐noise ratios, spatiotemporal resolution, and anatomical contrast for mapping CBF. Magn Reson Med 49:479–487, 2003. © 2003 Wiley‐Liss, Inc.