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In vivo multiple‐mouse imaging at 1.5 T
Author(s) -
Xu S.,
Gade T.P.F.,
Matei C.,
Zakian K.,
Alfieri A.A.,
Hu X.,
Holland E.C.,
Soghomonian S.,
Tjuvajev J.,
Ballon D.,
Koutcher J.A.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10397
Subject(s) - in vivo , scanner , magnetic resonance imaging , electromagnetic coil , nuclear medicine , radiofrequency coil , image resolution , preclinical imaging , resolution (logic) , nuclear magnetic resonance , biomedical engineering , pathology , medicine , radiology , physics , biology , computer science , optics , quantum mechanics , microbiology and biotechnology , artificial intelligence
A multiple‐mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156–176 μm in plane‐resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology ( P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner. Magn Reson Med 49:551–557, 2003. © 2003 Wiley‐Liss, Inc.