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Proton transverse relaxation rate ( R 2 ) images of iron‐loaded liver tissuepping local tissue iron concentrations with MRI
Author(s) -
Clark Paul R.,
Chuaanusorn Wanida,
St. Pierre Timothy G.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10378
Subject(s) - nuclear magnetic resonance , proton , relaxation (psychology) , transverse plane , magnetic resonance imaging , materials science , chemistry , nuclear medicine , physics , radiology , medicine , nuclear physics
Proton transverse relaxation rate ( R 2 ) imaging measurements were made on post mortem iron‐loaded human liver tissue samples (both intact and dissected into approximately 1‐cm cubes) from a single subject. Iron concentrations for the dissected samples as measured by atomic absorption spectrometry varied from 10.8 to 23.3 mg Fe.g −1 dry tissue. A significant linear correlation between the mean R 2 and iron concentration of each sample was found (r = 0.95). In addition, regions of liver tissue with micronodular cirrhosis exhibited lower R 2 values, corresponding to the displacement of iron by fibrotic septa. The cirrhotic tissue was clearly identified as a separate peak in the R 2 distribution of the tissue. The relaxivity of the iron did not appear to depend on the microarchitecture of the tissue. Magn Reson Med 49:572–575, 2003. © 2003 Wiley‐Liss, Inc.