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High‐resolution 3D proton spectroscopic imaging of the human brain at 3 T: SNR issues and application for anatomy‐matched voxel sizes
Author(s) -
Gruber Stephan,
Mlynárik Vladimir,
Moser Ewald
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10377
Subject(s) - voxel , nuclear magnetic resonance , image resolution , resolution (logic) , white matter , high resolution , laser linewidth , magnetic resonance imaging , nuclear medicine , materials science , physics , optics , computer science , medicine , artificial intelligence , radiology , laser , remote sensing , geology
In a systematic study on the interdependence of linewidth, signal‐to‐noise ratio (SNR), and spatial resolution in 3D proton spectroscopic imaging ( 1 H‐SI) at 3 T, we demonstrate reduced linewidths with increased spatial resolution due to reduced magnetic inhomogeneity within the brain. High‐precision quantitative data (0.75–0.094 cm 3 ) were obtained for all resolutions, enabling the creation of metabolic maps that display details such as the ventricles, sulci, and gyri. High‐resolution 1 H‐SI allows differences in metabolic ratios to be estimated for anatomically defined regions in gray (GM) and white matter (WM). Seven distinct regions in a healthy brain were anatomically segmented and their metabolic ratios were compared quantitatively. Data from a tumor patient are also presented to demonstrate potential clinical applications. Because of the high resolution, the metabolite ratios could be determined for distinct pathologic regions within the tumor and its surroundings. The method was additionally applied to a patient with patchy Pelizaeus Merzbacher disease (PMD), and compared to single‐voxel spectroscopy performed in the same session. High‐resolution SI data were demonstrated in our study to allow the direct matching of anatomic and metabolic images. This may enhance the clinical value of 1 H‐SI. Magn Reson Med 49:299–306, 2003. © 2003 Wiley‐Liss, Inc.