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Rapid measurement of time‐averaged blood flow using ungated spiral phase‐contrast
Author(s) -
Park Jong B.,
Olcott Eric W.,
Nishimura Dwight G.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10369
Subject(s) - pulsatile flow , imaging phantom , spiral (railway) , repeatability , blood flow , flip angle , biomedical engineering , phase contrast microscopy , contrast (vision) , in vivo , nuclear medicine , medicine , radiology , cardiology , magnetic resonance imaging , mathematics , physics , biology , mathematical analysis , statistics , microbiology and biotechnology , optics
A novel ungated spiral phase‐contrast (USPC) imaging method was developed for rapid measurement of time‐averaged blood‐flow rates in the presence of pulsatility. The spatial point‐spread function was analyzed to provide an intuitive understanding of how spiral trajectories, which sample the k ‐space origin at every excitation, can mitigate the effects of pulsatility. Pulsatile flow phantom experiments were performed to validate the accuracy and repeatability of the USPC method. The measurement of flow in the renal and femoral arteries of normal volunteers were also performed. The phantom results (error ≤ +9%, SD phantom ≤ 2%, time‐averaged pulsatile‐flow rates = 3–15 ml/s) and in vivo results (SD renal ≤ 8%, SD femoral ≤ 14%) demonstrate the potential of the USPC method for rapidly and repeatedly measuring accurate time‐averaged blood flow even in relatively small arteries and in the presence of strong pulsatility. Magn Reson Med 49:322–328, 2003. © 2003 Wiley‐Liss, Inc.