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Does binding of Gd‐DTPA to myocardial tissue contribute to late enhancement in a model of acute myocardial infarction?
Author(s) -
Decking Ulrich K.M.,
Pai Vinay M.,
Wen Han,
Balaban Robert S.
Publication year - 2003
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10324
Subject(s) - myocardial infarction , perfusion , saline , chemistry , diffusion , infarction , medicine , cardiology , nuclear magnetic resonance , physics , thermodynamics
The long‐lasting signal enhancement by Gd‐DTPA in areas of myocardial infarction has been conventionally explained by low perfusion and an enhanced Gd distribution volume. To test whether binding of Gd to myocardial constituents is an additional factor contributing to this effect, Gd‐DTPA was allowed to equilibrate between homogenized porcine myocardial tissue and physiological saline. The relaxation rate (1/ T 1 ) of homogenate samples (n = 61) increased in proportion (r 2 = 0.98) to the Gd concentration (0.025–0.5 mM) of the surrounding medium, with no evidence for augmented uptake. The diffusion‐limited uptake was only slightly more rapid than the subsequent Gd‐release. The amount of Gd released was in line with all of the Gd‐DTPA in the homogenate participating in water proton relaxation. The data from this acute myocardial infarction model do not support the notion that Gd‐DTPA binding in the early stages of myocardial damage contributes to delayed enhancement. Magn Reson Med 49:168–171, 2003. Published 2003 Wiley‐Liss, Inc.