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MRI of lungs using partial liquid ventilation with water‐in‐perfluorocarbon emulsions
Author(s) -
Huang Ming Qiang,
Ye Qing,
Williams Donald S.,
Ho Chien
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10231
Subject(s) - lung , ventilation (architecture) , medicine , lung cancer , in vivo , biomedical engineering , radiology , nuclear medicine , pathology , biology , mechanical engineering , microbiology and biotechnology , engineering
A novel 1 H‐MRI contrast modality for rat lungs has been developed using water‐in‐perfluorocarbon (PFC) emulsions for partial liquid ventilation™ (PLV). The feasibility of the new ventilation protocol for 1 H‐MRI studies of lungs has been demonstrated. 1 H‐MR images of lungs have been obtained with sensitivity and spatial resolution higher than those of the 19 F‐MRI of lungs previously reported. Diffusion‐weighted MRI measurements of lungs showed that the results obtained are related to the pulmonary architecture and functional properties of lungs. Although the methodology needs further improvement and evaluation, it appears to have great potential in a wide range of new applications in the field of lung MRI, such as in vivo detection of lung cancer, emphysema, and allograft rejection following lung transplantation. The ability of this technique to achieve high‐quality MR images of lungs, together with its technical simplicity, stability, and low cost, makes this method a promising imaging technique for the lungs. Magn Reson Med 48:487–492, 2002. © 2002 Wiley‐Liss, Inc.