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On the application of a non‐CPMG single‐shot fast spin‐echo sequence to diffusion tensor MRI of the human brain
Author(s) -
Bastin Mark E.,
Le Roux Patrick
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10214
Subject(s) - nuclear magnetic resonance , diffusion mri , spin echo , single shot , physics , fast spin echo , pulse sequence , tensor (intrinsic definition) , sensitivity (control systems) , chemistry , magnetic resonance imaging , optics , mathematics , medicine , radiology , electronic engineering , engineering , pure mathematics
The strong sensitivity of Carr‐Purcell‐Meiboom‐Gill (CPMG) fast spin‐echo (FSE) sequences, such as rapid acquisition with relaxation enhancement (RARE), to the phase of the prepared transverse magnetization means that artifact‐free single‐shot diffusion‐weighted images can currently only be obtained with a 30–50% reduction in the signal‐to‐noise ratio (SNR). However, this phase sensitivity and signal loss can be addressed in FSE sequences that use quadratic phase modulation of the radiofrequency (RF) refocusing pulses to generate a sustained train of stable echoes. Here the first application of such a non‐CPMG single‐shot FSE (ssFSE) sequence to diffusion tensor MR imaging (DT‐MRI) of the human brain is described. This approach provides high SNR diffusion‐weighted images that have little or no susceptibility to poor B 0 magnetic field homogeneity and the strong eddy currents typically present in DT‐MRI experiments. Magn Reson Med 48:6–14, 2002. © 2002 Wiley‐Liss, Inc.