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MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions
Author(s) -
Epstein Frederick H.,
Yang Zequan,
Gilson Wesley D.,
Berr Stuart S.,
Kramer Christopher M.,
French Brent A.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10210
Subject(s) - ejection fraction , myocardial infarction , medicine , cardiology , infarction , nuclear medicine , magnetic resonance imaging , cardiac function curve , radiology , heart failure
The purpose of this study was to use MR myocardial tagging to assess regional cardiac function after myocardial infarction (MI) in mice. Eight mice were imaged before and 1 day after MI. MRI included cine imaging, myocardial tagging, and contrast‐enhanced imaging. Regional percent circumferential shortening (%CS) was measured from the tagged images, and the region of hyperenhancement on the contrast‐enhanced images was used to determine the infarcted, adjacent, and remote zones. Ejection fraction (EF) fell from 59% ± 6% at baseline to 32% ± 6% after MI ( P < 0.01). At baseline, %CS was 14.5% ± 3.4%. After MI, %CS was 0.7% ± 4.4% in the infarcted zone, 7.4% ± 4.4% in the adjacent zone, and 11.8% ± 4.2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups ( P < 0.01). MR tagging can detect regional differences in myocardial function post‐MI in mice. Magn Reson Med 48:399–403, 2002. © 2002 Wiley‐Liss, Inc.