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Gastrointestinal transit times in mice and humans measured with 27 Al and 19 F nuclear magnetic resonance
Author(s) -
Schwarz Roman,
Kaspar Armin,
Seelig Joachim,
Künnecke Basil
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10207
Subject(s) - gastric emptying , stomach , chemistry , magnetic resonance imaging , nuclear magnetic resonance , gastrointestinal transit , nuclear medicine , gastrointestinal tract , medicine , physics , biochemistry , radiology
Gastric emptying and gastrointestinal (GI) transit times in mice and humans were monitored noninvasively by using 27 Al and 19 F nuclear magnetic resonance (NMR). Al 3+ bound to ion‐exchange resin and perfluorononane were administered orally as selective and specific markers for the stomach and the entire GI tract, respectively. 27 Al‐ and 19 F‐MR spectroscopy (MRS) was employed to follow quantitatively boli of the mixed markers in awake, fed mice over a period of 48 hr. The selectivity of the markers was confirmed by whole‐body 1 H‐, 27 Al‐, and 19 F‐MRI of anesthetized mice. Gastric emptying in humans was also monitored with 27 Al‐MRS of aluminum‐loaded ion exchange resin. GI transit was assessed by 19 F projection imaging of pharmaceutical capsules tagged with perfluorononane. Quantitative analysis of the MR data revealed that gastric emptying in humans proceeded linearly, whereas in mice an exponential decay was observed. This difference is explained by the respective feeding patterns of humans and mice. Humans usually achieve nearly complete gastric emptying before each meal. In contrast, very short delays between successive food intakes in small animals result in successive dilution of the stomach contents. For stomach emptying in mice the exponential decay constant was 74 min, whereas the half‐time of the linear gastric emptying in humans was 30 min. Magn Reson Med 48:255–261, 2002. © 2002 Wiley‐Liss, Inc.